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Nutritional Supplements

FlaxFit.com - Golden Flaxseed Tablet ForteCal.com - Fast Melting Calcium Supplement Fast Melting Toothpaste Tablet

Biomedical & Pharmaceutical Polymers

Aquagel.com - Superporous Hydrogel Technology Hytrocell - Technology for Poorly Water-Soluble Drugs Polyvivo.com - Biodegradable Block Copolymer Polyvitro - Drug Release Media Restiex - Tissue Expanding Hydrogel using Aquagel Technology Medical Grade Chitosan Fat Gel - Tissue Engineering Scaffold Flamma Fluor - Fluorescent Probes

Contract Research

Oral Tablet Formulations

Current R & D

Frosta - Fast Melting Tablet Technology Stentrix - Drug Eleuting Stent Technology Biodegradable Ureteral Stent

Hytrocell

Technology for Delivery of Poorly Water-Soluble Drugs

Clinical usefulness of many drugs are limited by their poor water-solubility. Akina has developed concepts of hydrotropic polymer (Hytrop®), hydrotropic hydrogel (HyTrogel®), and hydrotropic polymer micelle (HytroCell™).

Hytrops, HyTrogels, and HytroCelles are able to increase the aqueous solubilities of poorly soluble drugs by 2-4 orders of magnitudes. Akina has a series of Hytrops, HyTrogels, and HytroCells that can be used for solubilizing various poorly soluble drugs.

For example, HytroCelles based on PEG-b-poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide) (PEG-b-PVBDENA) can dissolve paclitaxel more than 30 wt% and yet they are stable in aqueous solution for weeks. None of the existing polymeric micelle systems have shown such a high loading efficiency with such a long-term stability. PEG-b-PVBDENA HytroCelles allows parenteral administration of paclitaxel using a very small volume for easy injection. Such HytroyCelles can also be formulated for oral administration of paclitaxel.

KEY BENEFITS:

PolyVivo: Biodegradable Block CoPolymers

Akina Inc. is currently selling high quality research grade biodegradable copolymers. These polymers are block copolymers of hydrophillic, biocompatible poly(ethylene glycol) (PEG) and biodegradable polymer, such as poly(lactide-co-glycolide) (PLGA), poly(caprolactone) (PCL), and poly(lactide) (PLA). These block copolymers are ideal for delivery of poorly soluble drugs, such as paclitaxel. These polymers can also be utilized for a wide variety of drug delivery platforms including hydrogels (AK08) and other formulations. The polymers shown are of research grade and are excellent tools for developing drug delivery technology.
PolyVivo Catalogue

PolyVitro: Drug Release Media

Also available from Akina is a new product PolyVitro.  This polymer based media modifier generates sink conditions without the characteristic hydrotropic peak which hinders HPLC analysis.  Regular strength PolyVitro has an everolimus solubility of 35 µg/ml while Extra-strength PolyVitro can dissolve everolimus to 50 µg/ml.
PolyVitro Catalogue

 

PolyVivo and PolyVitro are available by phone, mail, or email. For questions or to place an order talk directly to one of our scientists.
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If you have questions about our other products and services please visit our contact page.

Email:
jg@akinainc.com

Phone:
(765) 464-0501 Ext. 6#

Mail:
Akina, Inc.
ATTN: Polymer Sales
1291 Cumberland Ave.
West Lafayette, IN 47906